For couples who have experienced recurrent miscarriage, or several unsuccessful treatment cycles, at our center we recommend testing for DNA fragmentation within the sperm, as this can help us diagnose high levels of DNA fragmentation. It is also useful for men who have elevated leukocyte levels in the semen, have been exposed to toxic substances, are over 40 years of age, or have diabetes. The Sperm DNA fragmentation test measures the stability of the DNA in sperm and provides an estimate of the level of DNA damage in the sperm. Anti-oxidant therapy can be used to improve sperm health, or you may need ICSI treatment to select the best sperm.